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![Venetoclax resistance: mechanistic insights and future strategies](https://image.oaes.cc/25af2e02-1da6-43c8-b591-2f06681370c8/4740.fig.1.jpg)
Figure 1. Binding of BH3 mimetic, Venetoclax to BCL-2 anti-apoptotic protein releases bound BH3-only protein, subsequently allowing interaction between BH3-only protein and BAK/BAX. Upregulation of MCL-1, BCL-xL, and BCL2-A1 confers Venetoclax resistance by sequestration of BH3 only proteins, preventing them from interacting with BAK/BAX and avoidance of apoptosis[35-40].