fig2

Figure 2. A schematic figure of KRAS-driven signaling pathways in the regulation of metabolic signaling pathways. GLUT: Glucose transporters; HK: hexokinase; PFK: phosphofructokinase; PI3K: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; AKT: serine/threonine kinase; MAPK: mitogen-activated protein kinase 1; ERK: extracellular signal-regulated kinase 2; PDH: pyruvate dehydrogenase; PGK: phosphoglycerate kinase 1; HIF1α: hypoxia inducible factor 1 subunit alpha; JNK: mitogen-activated protein kinase 8; mTOR: mechanistic target of rapamycin kinase; LDHA/B: lactate dehydrogenase A/B; YAP: yes1 associated transcriptional regulator; IRF2: interferon regulatory factor 2; STAT3: signal transducer and activator of transcription 3; NF-κB: transcription factor P65; HSL: hormone-sensitive lipase; COX: cyclooxygenase; SCD: stearoyl-CoA desaturase; FASN: FA synthetase; ACLY: ATP-citrate lyase; GLS: glutaminase.