fig12

From: Liposome co-encapsulation of anti-cancer agents for pharmacological optimization of nanomedicine-based combination chemotherapy

Figure 12. Superior therapeutic activity of PLAD-MLP in the M109 tumor model (mouse lung carcinoma). BALB/c female mice were inoculated with 10⁶ tumor cells subcutaneously in the right rear footpad. Treatment given intravenously on days 5 and 12. When Dox and MLP are co-encapsulated, the doses are shown as Dox/MLP respectively. N mice/group = 5-8. Dose (1st → 2nd): PLD, 10 mg/kg → 8 mg/kg; PL-MLP, 35 mg/kg → 30 mg/kg; PLD+PL-MLP, 10 mg/kg + 13 mg/kg → 8 mg/kg + 10 mg/kg; PLAD-MLP, 10/13 mg/kg → 8/10 mg/kg. Statistical analysis of last 10 time points (Wilcoxon matched-pairs signed rank test) of PLAD-MLP vs the following groups: PLD+PL-MLP, P = 0.004; PLD, P = 0.002; PL-MLP, P non-significant