fig1
![Liposome co-encapsulation of anti-cancer agents for pharmacological optimization of nanomedicine-based combination chemotherapy](https://image.oaes.cc/5feda047-3964-41e2-a778-a3e225051f4d/3827.fig.1.jpg)
Figure 1. Schematic diagram of PLAD-MLP, a liposome formulation with co-encapsulated Ald, Dox and MLP (prodrug of MMC). A liposome formulation with MLP in the lipid bilayer and ammonium (NH4)Ald in the water phase is remote loaded with Dox, resulting in a multidrug liposome co-encapsulating two potent cytotoxic agents, and an immunomodulatory aminobisphosphonate (Ald). (NH4)Ald can be replaced with ammonium sulfate without affecting the remote loading of Dox