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![Oxidative stress and redox signaling in CRPC progression: therapeutic potential of clinically-tested Nrf2-activators](https://image.oaes.cc/83feba3b-4d0a-4160-88e6-084fa670f9e5/3805.fig.4.jpg)
Figure 4. Crosstalk regulation of Nrf-2, NF-κB and AR signaling in CRPC cells. Hormone deprivation (ADT) induced oxidative stress and redox signaling activates both NF-κB and AR signaling that facilitates CRPC progression. Oxidative stress also increases Nrf2 nuclear levels which blocks both NF-κB and AR signaling. Thus, reduction of oxidative stress post-ADT by using potent Nrf2-activating agents may prevent CRPC outgrowth. CRPC: castrate resistant prostate cancer; NF-κB: nuclear factor kappa B; AR: androgen receptor