fig9

Figure 9. Intracellular doxorubicin concentration (μmol/L) in A2780res cells. A2780res cells were incubated with DOX-NP, GC DOX-NP, and DOX solution at different DOX concentration (1, 5, 10 μmol/L) for 2 h (A) and 4 h (B). Then, the cells were lysed, and cell lysates were analyzed by HPLC. The results represent the mean ± SD. DOX: doxorubicin hydrochloride; GC: glycol chitosan-coated; DOX-NPs: DOX-loaded nanoparticles