fig5

Figure 5. Doxorubicin release from DOX-NPs and GC DOX-NPs (points, representing average values) fitted to kinetic models (lines). The in vitro release kinetics was fitted to each kinetic model by plotting: cumulative percent drug release vs. time for zero-order kinetic model, log of perscent drug remaining vs. time for first-order kinetic model, cumulative percent drug release versus square root of time for simplified Higuchi model, and log cumulative percent drug release versus log time for Korsmeyer-Peppas model. For DOX-NPs, the zero-order kinetic, the first-order kinetic and the Korsmeyer-Peppas models showed a high correlation with R² > 0.99. For GC DOX-NPs, the zero-order kinetic showed R² > 0.99. The R² values are reported in the table. DOX: doxorubicin hydrochloride; GC: glycol chitosan-coated; DOX-NPs: DOX-loaded nanoparticles