fig4

Figure 4. Putative Coactivator Domain of AKR1C3. Ribbon diagram of the AKR1C3•NADP⁺•Indomethacin complex (taken from PDB ID: 3UGB) showing the putative coactivator domain in the enzyme. Protein fold (green); NADP+ stick representation (red); indomethacin stick representation (orange); blue corresponds to amino acids 171-237; the disordered loop that may bind to the N-terminus of the AR (magneta). Cartoon prepared in PyMol