fig6

Figure 6. Simple somatic mutational analysis ABCB1 in human leukemias and other cancer types in the Cancer Genome Atlas (TCGA). A: at the time of analysis, there were 396 cases affected by 550 unique ABCA1 mutations across 27 projects, 446 cases by 500 ABCB1 mutations across 26 projects, 324 cases by 389 ABCC1 mutations across 27 projects, 361 cases by 407 CFTR mutations across 25 projects, and 181 cases affected by 206 ABCG2 mutations across 24 projects; B and C: ABC transporter gene (i.e., ABCA1, ABCB1, ABCC1, CFTR and ABCG2) mutations were compared with 7 frequently mutated genes (i.e., NRAS, KRAS, PTPN11, NPM1, FLT3, DNMT3A and IDH2) in leukemas as indicated; D-P: distribution of simple somatic mutations (SSMs) in TCGA projects with the frequency (%) of SSMs in TCGA-LAML (i.e., TCGA project name: acute myeloid leukemia, n = 144 cases) indicated by red-colored columns; Q: detailed information and abbreviations with respect to TCGA projects used in Figure 7. SSM affected cases (%) is calculated on the basis of the ratios between the number of cases for SSMs in an individual project affected by each individual gene of interest and the number of cases (as listed in Figure 6Q) tested for SSMs in that project