fig1

Figure 1. PHGDH expression drives resistance to a variety of chemotherapeutics (shown in red) through modulation of metabolic pathways. 3PG: 3-phosphoglycerate; 2PG: 2-phosphoglycerate; PEP: phosphoenolpyruvate; PKM2: pyruvate kinase M2; TCA cycle: citric acid cycle; αKG: α-ketoglutarate; D-2HG: D-2-hydroxyglutarate; PHGDH: 3-phosphoglycerate dehydrogenase; 3-PHP: 3-phosphohydroxypyruvate; PSAT: phosphoserine aminotransferase; 3PS: 3-phosphoserine; PSPH: phosphoserine phosphatase; NAD⁺: nicotinamide adenine dinucleotide, oxidized; NADH: nicotinamide adenine dinucleotide, reduced; Glu: glutamate; SHMT: serine hydroxymethyltransferase; DHFR: dihydrofolate reductase