fig5
![Nitric oxide-elicited resistance to anti-glioblastoma photodynamic therapy](https://image.oaes.cc/a67f3e39-6061-43d7-9668-76945676b518/3612.fig.5.jpg)
Figure 5. Upstream signaling events elicited by photodynamic therapy (Ala/light) leading ultimately to inducible nitric oxide synthase (iNOS) transcriptional upregulation. Key effector proteins (Akt, PI3K, p300, p65, Sirt1) are shown along with key inhibitors (His, LY294002, C646) and their targets[48]