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From:  Identification of sequence-specific interactions of the CD44-intracellular domain with RUNX2 in the transcription of matrix metalloprotease-9 in human prostate cancer cells
Identification of sequence-specific interactions of the CD44-intracellular domain with RUNX2 in the transcription of matrix metalloprotease-9 in human prostate cancer cells

Figure 8. Schematic diagram illustrating the proposed mechanism of CD44-ICD-DelConstruct-RUNX2 interaction in PC3 cells. CD44 is sequentially cleaved to generate CD44-intracellular domain (ICD) fragment. CD44-ICD-FL, D1, D2 and D3 fragments interact with RUNX2 in the nucleus of PC3 cells to activate transcription of MMP-9 to promote tumor progression via migration and metastasis. CD44: Cluster of differentiation 44

Cancer Drug Resistance
ISSN 2578-532X (Online)
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