fig7
![DNA direct reversal repair and alkylating agent drug resistance](https://image.oaes.cc/2aa80543-de21-4895-8962-66b0d201e8f5/3924.fig.7.jpg)
Figure 7. Glutamine metabolism producing 2-oxoglutarate. Enzymes are indicated in blue. ALKBHs represents ALKBH2 and ALKBH3 proteins that require αKG as a cofactor in this review. Gln: Glutamine; Glu: glutamate; αKG: α-ketoglutarate, ISC: isocitrate; TCA: tricarboxylic acid cycle; GDH: glutamate dehydrogenase; GLS: glutaminase; GOT: glutamate oxaloacetate transaminase; IDH: isocitrate dehydrogenases.