fig6

Figure 6. 1-methyladenine:adenine and 3-methylcytosine:adenine base pairings, which lead to A→T and C→T mutations, respectively. These possible base pairing schemes are derived from the observation of mutations in a mouse model system with Alkbh2 or Alkbh3 deleted^[48]. The 3-methylcytosine (3-meC) modified base would most probably use a translesion DNA polymerase for insertion opposite 3-meC due to the single-base pairing available with the modification at the N3 position. Note that the left 1-meA:A pair would be in a parallel helix, whereas the right structure would be in an antiparallel helix.