fig1
Figure 1. Selected chemotherapeutic alkylating agents. DNA damage is monofunctional (temozolomide, CCNU) or bifunctional (nitrogen mustard, melphalan, busulfan). Alkylating agents use SN1 (temozolomide, CCNU) or SN2 mechanisms (nitrogen mustard, melphalan, busulfan). The red portions of the structure are the moieties that alkylate DNA.
