fig1
![Carbonic anhydrase XII inhibition overcomes P-glycoprotein-mediated drug resistance: a potential new combination therapy in cancer](https://image.oaes.cc/fedabb8d-516b-46d9-9a9e-52c6ee721e55/3884.fig.1.jpg)
Figure 1. CAs IX and XII support pH homeostasis of the tumor microenvironment, involving both intracellular (pHi) and extracellular (pHe). CA: carbonic anhydrase, **HCO3- is either co-transported with Na+ ions or exchanged for Cl- ions (via anion exchangers).