fig4

From: ABCA1 is associated with the development of acquired chemotherapy resistance and predicts poor ovarian cancer outcome

Figure 4. ABCA1 mRNA expression is increased in ovarian cancer cells with acquired carboplatin resistance. (A) ABCA1; (B) ABCB1; (C) ABCB3; (D) ABCC2; and (E) ABCG2 expression in parental (OVCAR-5 and CaOV3) and carboplatin resistant ovarian cancer cell lines (OVCAR-5 CBPR and CaOV3 CBPR). For the cell line, the columns represent the mean fold changes ± SEM from 12-20 RNA samples from 4-6 independent experiments. *P < 0.05, unpaired t test. Data for the primary HGSOC cells from patients with chemosensitive at diagnosis (n = 9) or acquired chemoresistance following relapse (n = 6) are expressed as the median fold change from 3-6 RNA samples from two independent experiments. *P = 0.026, Mann-Whitney U test. ABCB1 was not detectable in OVCAR-5 cells.