fig1
![Entrapment of DNA topoisomerase-DNA complexes by nucleotide/nucleoside analogs](https://image.oaes.cc/003d858e-86bb-4e1d-932b-a44ad004ac14/3282.fig.1.jpg)
Figure 1. Substitution of nucleoside analogs into a model Top1 cleavage site results in Top1cc. (Top) The chemical structures for three nucleoside analogs that induce Top1cc in genomic DNA; (Middle) sequence of a model Top1cc used to investigate nucleoside analog substitution effects on Top1cc with the +1 site in the non-scissile strand highlighted; and (Bottom) 23mer model Top1cc substrate used to study cleavage/re-ligation effects of nucleoside analogs. *A corresponds to the [32P]-cordycepin label. Modified from References[27,39,46]. Top1: topoisomerase 1; AraC: cytarabine; GEM: gemcitabine; FdU: 5-fluoro-2’-deoxyuridine; Top1cc: Top1 cleavage complex