fig7

Figure 7. Cellular uptake of ^99mTc-DMEOP, ^99mTc-TMEOP, and ^99mTc-Sestamibi in several human drug resistant cancer cell lines: MCF7 Pgp and H69 Lx4 overexpressing the Pgp protein and H69 AR overexpressing MRP1. For comparison, the uptake curves in the corresponding non-resistant cell lines, MCF7 and H69 (discontinuous lines), are also represented. The results are presented as the percentage of cell-associated radioactivity normalized to 10⁶ cells over time, were calculated from independent biological replicates (n = 3-4), and are given as the average ± SEM. Pgp: P-glycoprotein; MRP1: multidrug-resistant protein 1