REFERENCES

1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin 2019;69:7-34.

2. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68:394-424.

3. Calin GA, Trapasso F, Shimizu M, Dumitru CD, Yendamuri S, et al. Familial cancer associated with a polymorphism in ARLTS1. N Engl J Med 2005;352:1667-76.

4. Zhou Y, Wan G, Spizzo R, Ivan C, Mathur R, et al. miR-203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase. Mol Oncol 2014;8:83-92.

5. Garcia-Mayea Y, Mir C, Masson F, Paciucci R, LLeonart ME. Insights into new mechanisms and models of cancer stem cell multidrug resistance. Semin Cancer Biol 2019; doi: 10.1016/j.semcancer.2019.07.022.

6. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.

7. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.

8. Bahrami A, Hassanian SM, Khazaei M, Hasanzadeh M, Shahidsales S, et al. The therapeutic potential of targeting tumor microenvironment in breast cancer: rational strategies and recent progress. J Cell Biochem 2018;119:111-22.

9. Soysal SD, Tzankov A, Muenst SE. Role of the tumor microenvironment in breast cancer. Pathobiology 2015;82:142-52.

10. Jin L, Wessely O, Marcusson EG, Ivan C, Calin GA, et al. Prooncogenic factors miR-23b and miR-27b are regulated by Her2/Neu, EGF, and TNF-α in breast cancer. Cancer Res 2013;73:2884-96.

11. Hu M, Yao J, Cai L, Bachman KE, van den Brûle F, et al. Distinct epigenetic changes in the stromal cells of breast cancers. Nat Genet 2005;37:899-905.

12. Obenauf AC, Zou Y, Ji AL, Vanharanta S, Shu W, et al. Therapy-induced tumour secretomes promote resistance and tumour progression. Nature 2015;520:368-72.

13. Easwaran H, Tsai HC, Baylin SB. Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance. Mol Cell 2014;54:716-27.

14. Fabbri M, Calin GA. Epigenetics and miRNAs in human cancer. Adv Genet 2010;70:87-99.

15. Mittal S, Brown NJ, Holen I. The breast tumor microenvironment: role in cancer development, progression and response to therapy. Expert Rev Mol Diagn 2018;18:227-43.

16. Müller A, Homey B, Soto H, Ge N, Catron D, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001;410:50-6.

17. Dragomir M, Chen B, Calin GA. Exosomal lncRNAs as new players in cell-to-cell communication. Transl Cancer Res 2018;7:S243-52.

18. Bayraktar R, Van Roosbroeck K, Calin GA. Cell-to-cell communication: microRNAs as hormones. Mol Oncol 2017;11:1673-86.

19. Tkach M, Théry C. Communication by extracellular vesicles: where we are and where we need to go. Cell 2016;164:1226-32.

20. van Niel G, D’Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol 2018;19:213-28.

21. Mathieu M, Martin-Jaular L, Lavieu G, Théry C. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol 2019;21:9-17.

22. Colombo M, Raposo G, Théry C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol 2014;30:255-89.

23. Anfossi S, Babayan A, Pantel K, Calin GA. Clinical utility of circulating non-coding RNAs - an update. Nat Rev Clin Oncol 2018;15:541-63.

24. Sung BH, Ketova T, Hoshino D, Zijlstra A, Weaver AM. Directional cell movement through tissues is controlled by exosome secretion. Nat Commun 2015;6:7164.

25. Qu L, Ding J, Chen C, Wu ZJ, Liu B, et al. Exosome-transmitted lncARSR promotes sunitinib resistance in renal cancer by acting as a competing endogenous RNA. Cancer Cell 2016;29:653-68.

26. Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, et al. Tumour exosome integrins determine organotropic metastasis. Nature 2015;527:329-35.

27. Costa-Silva B, Aiello NM, Ocean AJ, Singh S, Zhang H, et al. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nat Cell Biol 2015;17:816-26.

28. Peinado H, Alečković M, Lavotshkin S, Matei I, Costa-Silva B, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med 2012;18:883-91.

29. Zhang HG, Grizzle WE. Exosomes: a novel pathway of local and distant intercellular communication that facilitates the growth and metastasis of neoplastic lesions. Am J Pathol 2014;184:28-41.

30. Chen X, Ying X, Wang X, Wu X, Zhu Q, et al. Exosomes derived from hypoxic epithelial ovarian cancer deliver microRNA-940 to induce macrophage M2 polarization. Oncol Rep 2017;38:522-28.

31. Zhu L, Kalimuthu S, Gangadaran P, Oh JM, Lee HW, et al. Exosomes derived from natural killer cells exert therapeutic effect in melanoma. Theranostics 2017;7:2732-45.

32. ussard KM, Mutkus L, Stumpf K, Gomez-Manzano C, Marini FC. Tumor-associated stromal cells as key contributors to the tumor microenvironment. Breast Cancer Res 2016;18:84.

33. Gutkin A, Uziel O, Beery E, Nordenberg J, Pinchasi M, et al. Tumor cells derived exosomes contain hTERT mRNA and transform nonmalignant fibroblasts into telomerase positive cells. Oncotarget 2016;7:59173-88.

34. Zhao H, Yang L, Baddour J, Achreja A, Bernard V, et al. Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism. Elife 2016;5:e10250.

35. Raposo G. B lymphocytes secrete antigen-presenting vesicles. J Exp Med 1996;183:1161-72.

36. Zitvogel L, Regnault A, Lozier A, Wolfers J, Flament C, et al. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat Med 1998;4:594-600.

37. Jean-Philippe J, Paz S, Caputi M. hnRNP A1: The Swiss Army Knife of Gene Expression. Int J Mol Sci 2013;14:18999-9024.

38. Villarroya-Beltri C, Gutiérrez-Vázquez C, Sánchez-Cabo F, Pérez-Hernández D, Vázquez J, et al. Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs. Nat Commun 2013;4:2980.

39. Vasilescu C, Tanase M, Dragomir M, Calin GA. From mobility to crosstalk. A model of intracellular miRNAs motion may explain the RNAs interaction mechanism on the basis of target subcellular localization. Math Biosci 2016;280:50-61.

40. Colombo M, Moita C, van Niel G, Kowal J, Vigneron J, et al. Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. J Cell Sci 2013;126:5553-65.

41. Hurley JH. ESCRTs are everywhere. EMBO J 2015;34:2398-2407.

42. Guo BB, Bellingham SA, Hill AF. The Neutral Sphingomyelinase Pathway Regulates Packaging of the Prion Protein into Exosomes. J Biol Chem 2015;290:3455-67.

43. van Niel G, Charrin S, Simoes S, Romao M, Rochin L, et al. The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis. Dev Cell 2011;21:708-21.

44. Seabra MC, Mules EH, Hume AN. Rab GTPases, intracellular traffic and disease. Trends Mol Med 2002;8:23-30.

45. strowski M, Carmo NB, Krumeich S, Fanget I, Raposo G, et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol 2010;12:19-30.

46. ader CM, Sánchez DG, Mestre MB, Colombo MI. TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways. Biochim Biophys Acta - Mol Cell Res 2009;1793:1901-16.

47. ogozzi M, Mizzoni D, Angelini D, Di Raimo R, Falchi M, et al. Microenvironmental pH and exosome levels interplay in human Cancer cell lines of different Histotypes. Cancers 2018;10:370.

48. Shapiro AB, Ling V. The mechanism of ATP-dependent multidrug transport by P-glycoprotein. Acta Physiol Scand Suppl 1998;643:227-34.

49. Torreggiani E, Roncuzzi L, Perut F, Zini N, Baldini N. Multimodal transfer of MDR by exosomes in human osteosarcoma. Int J Oncol 2016;49:189-96.

50. ato T, Mizutani K, Kameyama K, Kawakami K, Fujita Y, et al. Serum exosomal P-glycoprotein is a potential marker to diagnose docetaxel resistance and select a taxoid for patients with prostate cancer. Urol Oncol Semin Orig Investig 2015;33:385.e15-20.

51. Aung T, Chapuy B, Vogel D, Wenzel D, Oppermann M, et al. Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3. Proc Natl Acad Sci 2011;108:15336-41.

52. Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007;9:654-59.

53. Mattick JS, Makunin I V. Non-coding RNA. Hum Mol Genet 2006;15:R17-29.

54. Feeley KP, Edmonds MD. Hiding in plain sight: rediscovering the importance of noncoding RNA in human malignancy. Cancer Res 2018;78:2149-58.

55. Fabbri M, Garzon R, Andreeff M, Kantarjian HM, Garcia-Manero G, et al. MicroRNAs and noncoding RNAs in hematological malignancies: molecular, clinical and therapeutic implications. Leukemia 2008;22:1095-105.

56. Almeida MI, Nicoloso MS, Zeng L, Ivan C, Spizzo R, et al. Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells. Gastroenterology 2012;142:886-96.e9.

57. Peng C, Wang Y-L. Editorial: microRNAs as new players in endocrinology. Front Endocrinol (Lausanne) 2018;9:459.

58. Berindan-Neagoe I, Calin GA. Molecular pathways: MicroRNAs, cancer cells, and microenvironment. Clin Cancer Res 2014;20:6247-53.

59. O’Brien J, Hayder H, Zayed Y, Peng C. Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne) 2018;9:402.

60. Hannafon BN, Trigoso YD, Calloway CL, Zhao YD, Lum DH, et al. Plasma exosome microRNAs are indicative of breast cancer. Breast Cancer Res 2016;18:90.

61. Figueroa J, Phillips LM, Shahar T, Hossain A, Gumin J, et al. Exosomes from glioma-associated mesenchymal stem cells increase the tumorigenicity of glioma stem-like cells via transfer of miR-1587. Cancer Res 2017;77:5808-19.

62. Qin X, Yu S, Zhou L, Shi M, Hu Y, et al. Cisplatin-resistant lung cancer cell-derived exosomes increase cisplatin resistance of recipient cells in exosomal miR-100-5p-dependent manner. Int J Nanomedicine 2017;12:3721-33.

63. Bach DH, Hong JY, Park HJ, Lee SK. The role of exosomes and miRNAs in drug-resistance of cancer cells. Int J Cancer 2017;141:220-30.

64. Acunzo M, Romano G, Wernicke D, Croce CM. MicroRNA and cancer - A brief overview. Adv Biol Regul 2015;57:1-9.

65. Berteaux N, Lottin S, Monté D, Pinte S, Quatannens B, et al. H19 mRNA-like noncoding RNA promotes breast cancer cell proliferation through positive control by E2F1. J Biol Chem 2005;280:29625-36.

66. Bhat SA, Ahmad SM, Mumtaz PT, Malik AA, Dar MA, et al. Long non-coding RNAs: mechanism of action and functional utility. Non-coding RNA Res 2016;1:43-50.

67. Wang KC, Chang HY. Molecular mechanisms of long noncoding RNAs. Mol Cell 2011;43:904-14.

68. Shah MY, Ferracin M, Pileczki V, Chen B, Redis R, et al. Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations. Genome Res 2018;28:432-47.

69. Rigoutsos I, Lee SK, Nam SY, Anfossi S, Pasculli B, et al. N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration. Genome Biol 2017;18:98.

70. Brown CJ, Lafreniere RG, Powers VE, Sebastio G, Ballabio A, et al. Localization of the X inactivation centre on the human X chromosome in Xq13. Nature 1991;349:82-4.

71. Long Y, Wang X, Youmans DT, Cech TR. How do lncRNAs regulate transcription? Sci Adv 2017;3:eaao2110.

72. Bi H, Yang X, Yuan J, Yang F, Xu D, et al. H19 inhibits RNA polymerase II-mediated transcription by disrupting the hnRNP U-actin complex. Biochim Biophys Acta - Gen Subj 2013;1830:4899-906.

73. Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP. A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell 2011;146:353-8.

74. Shan Y, Ma J, Pan Y, Hu J, Liu B, et al. LncRNA SNHG7 sponges miR-216b to promote proliferation and liver metastasis of colorectal cancer through upregulating GALNT1. Cell Death Dis 2018;9:722.

75. Chen F, Wang N, Tan HY, Guo W, Zhang C, et al. The functional roles of exosomes-derived long non-coding RNA in human cancer. Cancer Biol Ther 2019;20:583-92.

76. Wu D, Ni J, Beretov J, Cozzi P, Willcox M, et al. Urinary biomarkers in prostate cancer detection and monitoring progression. Crit Rev Oncol Hematol 2017;118:15-26.

77. Hessels D, Klein Gunnewiek JMT, van Oort I, Karthaus HFM, van Leenders GJL, et al. DD3(PCA3)-based molecular urine analysis for the diagnosis of prostate cancer. Eur Urol 2003;44:8-16.

78. Jiang N, Pan J, Fang S, Zhou C, Han Y, et al. Liquid biopsy: circulating exosomal long noncoding RNAs in cancer. Clin Chim Acta 2019;495:331-7.

79. Zhang R, Xia Y, Wang Z, Zheng J, Chen Y, et al. Serum long non coding RNA MALAT-1 protected by exosomes is up-regulated and promotes cell proliferation and migration in non-small cell lung cancer. Biochem Biophys Res Commun 2017;490:406-14.

80. Li C, Lv Y, Shao C, Chen C, Zhang T, et al. Tumor-derived exosomal lncRNA GAS5 as a biomarker for early-stage non-small-cell lung cancer diagnosis. J Cell Physiol 2019;234:20721-7.

81. Teng Y, Kang H, Chu Y. Identification of an Exosomal Long Noncoding RNA SOX2-OT in Plasma as a Promising Biomarker for Lung Squamous Cell Carcinoma. Genet Test Mol Biomarkers 2019;23:235-40.

82. Lang HL, Hu GW, Chen Y, Liu Y, Tu W, et al. Glioma cells promote angiogenesis through the release of exosomes containing long non-coding RNA POU3F3. Eur Rev Med Pharmacol Sci 2017;21:959-72.

83. Li Z, Jiang P, Li J, Peng M, Zhao X, et al. Tumor-derived exosomal lnc-Sox2ot promotes EMT and stemness by acting as a ceRNA in pancreatic ductal adenocarcinoma. Oncogene 2018;37:3822-38.

84. Hardin H, Helein H, Meyer K, Robertson S, Zhang R, et al. Thyroid cancer stem-like cell exosomes: regulation of EMT via transfer of lncRNAs. Lab Investig 2018;98:1133-42.

85. Li X, Lei Y, Wu M, Li N. Regulation of macrophage activation and polarization by HCC-derived exosomal lncRNA TUC339. Int J Mol Sci 2018;19.

86. Pérez-Herrero E, Fernández-Medarde A. Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy. Eur J Pharm Biopharm 2015;93:52-79.

87. Zhang Z, Yin J, Lu C, Wei Y, Zeng A, et al. Exosomal transfer of long non-coding RNA SBF2-AS1 enhances chemoresistance to temozolomide in glioblastoma. J Exp Clin Cancer Res 2019;38:166.

88. Takahashi K, Yan IK, Wood J, Haga H, Patel T. Involvement of extracellular vesicle long noncoding RNA (linc-VLDLR) in tumor cell responses to chemotherapy. Mol Cancer Res 2014;12:1377-87.

89. Takahashi K, Yan IK, Kogure T, Haga H, Patel T. Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer. FEBS Open Bio 2014;4:458-67.

90. Dong H, Wang W, Chen R, Zhang Y, Zou K, et al. Exosome-mediated transfer of lncRNA-SNHG14 promotes trastuzumab chemoresistance in breast cancer. Int J Oncol 2018;53:1013-26.

91. Yang Y, Zhang R, Du J, Yuan H, Li Y, et al. Predictive role of UCA1-containing exosomes in cetuximab-resistant colorectal cancer. Cancer Cell Int 2018;18:164.

92. Kang M, Ren M, Li Y, Fu Y, Deng M, et al. Exosome-mediated transfer of lncRNA PART1 induces gefitinib resistance in esophageal squamous cell carcinoma via functioning as a competing endogenous RNA. J Exp Clin Cancer Res 2018;37:171.

93. Lei Y, Guo W, Chen B, Chen L, Gong J, et al. Tumor-released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non-small cell lung cancer. Oncol Rep 2018;40:3438-46.

94. Zhang W, Cai X, Yu J, Lu X, Qian Q, et al. Exosome-mediated transfer of lncRNA RP11-838N2.4 promotes erlotinib resistance in non-small cell lung cancer. Int J Oncol 2018;53:527-38.

95. Dunnwald LK, Rossing MA, Li CI. Hormone receptor status, tumor characteristics, and prognosis: a prospective cohort of breast cancer patients. Breast Cancer Res 2007;9:R6.

96. Gomez-Fernandez C, Daneshbod Y, Nassiri M, Milikowski C, Alvarez C, et al. Immunohistochemically determined estrogen receptor phenotype remains stable in recurrent and metastatic breast cancer. Am J Clin Pathol 2008;130:879-82.

97. Harbeck N, Gnant M. Breast cancer. Lancet 2017;389:1134-50.

98. Shagufta Ahmad I. Tamoxifen a pioneering drug: an update on the therapeutic potential of tamoxifen derivatives. Eur J Med Chem 2018;143:515-31.

99. Xu CG, Yang MF, Ren YQ, Wu CH, Wang LQ. Exosomes mediated transfer of lncRNA UCA1 results in increased tamoxifen resistance in breast cancer cells. Eur Rev Med Pharmacol Sci 2016;20:4362-8.

100. Abril-Rodriguez G, Ribas A. SnapShot: immune checkpoint inhibitors. Cancer Cell 2017;31:848-848.e1.

101. Jaafar J, Fernandez E, Alwan H, Philippe J. Programmed cell death-1 and programmed cell death ligand-1 antibodies-induced dysthyroidism. Endocr Connect 2018;7:R196-211.

102. Nanda R, Chow LQM, Dees EC, Berger R, Gupta S, et al. Pembrolizumab in patients with advanced triple-negative breast cancer: phase Ib KEYNOTE-012 study. J Clin Oncol 2016;34:2460-7.

103. Hu Q, Ye Y, Chan LC, Li Y, Liang K, et al. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nat Immunol 2019;20:835-51.

Cancer Drug Resistance
ISSN 2578-532X (Online)

Portico

All published articles will preserved here permanently:

https://www.portico.org/publishers/oae/

Portico

All published articles will preserved here permanently:

https://www.portico.org/publishers/oae/