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![Network rewiring, adaptive resistance and combating strategies in breast cancer](https://image.oaes.cc/d7f37250-9f19-4471-9241-be13ee438904/3241.fig.2.jpg)
Figure 2. MEK inhibition dynamically reprograms the kinome and RTK signalling network. A: Inhibition of MEK disrupts a repressing transcriptional program exerted by the transcriptional factor c-Myc on the RTKs, which leads to induced expression and activation of an array of RTKs; B: MEK inhibition triggers a dynamic genome-wide enhancer formation with pronounced BRD4 density co-occupied with typical enhancer marks, causing increased expression and subsequent activation of RTKs, including PDGFRB, FGFR2, and DDR1