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![Network rewiring, adaptive resistance and combating strategies in breast cancer](https://image.oaes.cc/d7f37250-9f19-4471-9241-be13ee438904/3241.fig.1.jpg)
Figure 1. A: Frequency of alterations of PTEN and PIK3CA in breast cancer patients by subtype, analysed using the Pan-cancer Atlas dataset (n = 994) from The Cancer Genome Atlas Program (www.cbioportal.org); B: Signalling crosstalk between the PI3K and MAPK signalling pathways, with examples of targeted inhibitors directed at the network nodes