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![Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies](https://image.oaes.cc/f8842838-ac00-4722-bd2a-6c96768a2e5d/3204.fig.4.jpg)
Figure 4. Cooperativity of NRF2 and HER family receptors in cellular proliferation and cancer. The NRF2-ARE pathway cross-talks with the HER family receptor and other signalling pathways. This provides rationale and justification for the use and design of anticancer drugs and/or molecules that target HER family receptors and/or target NRF2 to enhance the action and effectiveness of HER targeting anticancer therapies and delay or overcome resistance. NRF2: nuclear factor E2-related factor 2