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![Role of circulating tumor cell spheroids in drug resistance](https://image.oaes.cc/1567db84-a230-4d3b-9c9b-ea0a24dab119/3161.fig.1.jpg)
Figure 1. A: Depicts a poorly vascularized tumor region showing gradients of oxygen, nutrients and waste; B: shows an overlay of a large tumorosphere of a patient which has transformed from NSCLC under Osimertinib treatment to SCLC. The corresponding gradients are shown for the tumorosphere. NSCLC: non-small-cell lung cancer; SCLC: small-cell lung cancer