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From: Drug resistance mechanisms of cancer stem-like cells and their therapeutic potential as drug targets
Figure 3. Stemness related pathways could be useful for targeting CSCs. When Wnt binds to FZD receptor, it downregulates the function of AXIN/GSK-3/APC complex, which leads to stabilization of β-catenin. Stabilized β-catenin moves into nucleus and induces the stemness related gene expressions. When a transmembrane Notch ligand (Delta or Jagged) on one cell binds to a transmembrane receptor (Notches 1-4) on a neighboring cell, the receptor is cleaved and interact with nuclear factors to regulate stemness related gene expressions. Inhibition of these pathways may contribute to CSC eradication. FZD: frizzled; GSK-3: glycogen synthase kinase-3; APC: adenomatous polyposis coli. CSCs: cancer stem-like cells
