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![Enhanced Kat3A/Catenin transcription: a common mechanism of therapeutic resistance](https://image.oaes.cc/2c542f85-d3c5-4780-acb5-9060ba24dd8b/3138.fig.2.jpg)
Figure 2. Coordination and integration of multiple signaling cascades is required to regulate the decision of a stem cell to either differentiate or self-renew. Multiple signaling inputs both intrinsic and extrinsic, including nutrient and oxygen levels, growth factors and various signaling cascades must be integrated and funneled down to regulate a transcriptional program either leading to self-renewal or the initiation of differentiation