fig4
![Emerging consensus on the mechanism of polyspecific substrate recognition by the multidrug transporter P-glycoprotein](https://image.oaes.cc/98c90cd1-0835-405c-90d1-b44d756d6134/3135.fig.4.jpg)
Figure 4. Conserved coupling interface between ICD and NBD (A) Structural alignment of NBD1s from the structures of mP-gp with different DCOM values. The alignment of NBD1 also brings ICD1 to superposition, whereas the rest of P-gp is not aligned. (B) Here, structural alignment is carried out for NBD2s from structures of mP-gp with different DCOM values. The alignment of NBD2 also brings ICD2 to superposition, but not the rest of P-gp