fig5
Figure 5. Ligand orientation in the hydrophobic binding pocket of K-RAS 4B. Co-crystal structure of (2) with K-RAS G12V (aa 1-169) [4EPY] in surface projection. The co-crystal structure of (1) [4DST] and (6) [6FA4] as well as (3) docked to [4DSO] have been aligned to 4EPY. The compounds are color-coded as follows: (1) blue; (2) green; (3) magenta; (6) red. The switch regions adjacent to the hydrophobic binding pocket are labeled switch I SW-I (yellow) and switch II SW-II (orange)
