fig7
From: Use of MRI, metabolomic, and genomic biomarkers to identify mechanisms of chemoresistance in glioma
![Use of MRI, metabolomic, and genomic biomarkers to identify mechanisms of chemoresistance in glioma](https://image.oaes.cc/fbb06c61-f02a-4138-a742-4ae4f2014e4d/3128.fig.7.jpg)
Figure 7. Effect of BCNU exposure to 9L rat glioma cells. Cells were exposed to 150 µM (9L-R1) or 225 µM (9L-R2) in culture or in vivo (9L-R3) after intracranial implantation (26.6 mg/kg body weight). RNA was subjected to 12-plex microarray to determine changes in gene expression compared to drug naïve cells (9L-S). Venn diagram illustrates the number of genes differentially regulated (P ≤ 0.05) in each of the three BCNU-resistant cell lines