fig3
From: Use of MRI, metabolomic, and genomic biomarkers to identify mechanisms of chemoresistance in glioma
Figure 3. Effect of chemoresistance on aspartate isotopomer ratios. A: Model depicting the pathways for aspartate M2 and M3 isotopomer production from U-13C glucose; B: Aspartate M3:M2 isotopomer ratios in BCNU-sensitive (9L-S) and BCNU-resistant (9L-R) glioma cells in the absence and presence of 40 mM DCA. Bars (mean ± SD, n = 6) with different letters are significantly different from each other at P ≤ 0.05. PC: pyruvate carboxylase; PDH: pyruvate dehydrogenase; ME: malic enzyme
