fig9

Figure 9. Schematic representation showing the mechanism of action of Nef in overcoming Dox resistance in lung cancer cells. Nef in combination with Dox increases ROS levels which in turn leads to NRF2 mediated LRP downregulation. This effect leads to the increased Dox levels in the lung cancer cells and cell death. Nef: Neferine; Dox: Doxorubicin; NRF2: nuclear factor erythroid-derived 2-like 2; LRP: lung resistance protein; ROS: Reactive oxygen species