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![Cancer stem cells, plasticity, and drug resistance](https://image.oaes.cc/c9feefa0-a12f-49c9-aae4-380157510f2c/3355.fig.2.jpg)
Figure 2. A: tumor target therapy. Simplified schematic of the key molecular component of MAPK and PI3K/Akt signaling pathway related to melanoma tumorigenesis and targeted inhibitors of representative drugs and therapies with the main resistant mechanisms. B: immunotherapy. The target of the tumor cell environment, the most important drugs, and the main resistance mechanisms. HLA: human leukocyte antigen