fig1

Figure 1. Schematic diagram illustrating the signalling pathways targeted by ibrutinib, idelalisib and venetoclax in CLL (A) and the known mechanisms of resistance to each of these agents (B) in CLL cells. CLL: chronic lymphocytic leukaemia; Btk: bruton's tyrosine kinase; LYN: Lck/Yes novel tyrosine kinase; AKT: protein kinase B; SYK: spleen tyrosine kinase; PKC: protein kinase C; BCL: B-cell Lymphoma; MCL-1: myeloid leukemia cell differentiation protein; mTOR: mammalian target of rapamycin