fig1

Figure 1. Roles of oncomiRs and suppressor miRNAs in carcinogenesis pathways of HCC. Red: oncomiRs; blue: suppressor miRNAs. PTEN: phosphatase and tensin homolog; oncomiRs: oncogenic miRNAs; miRNAs: microRNAs; HCC: hepatocellular carcinoma; PI3K: phosphoinositide 3-kinase; MAPK: mitogen-activated protein kinases; MET: mesenchymal-epithelial transition factor; PAC4: proteasome assembly chaperone 4 ; ERK: extracellular regulated kinase; MDM: mouse double minute; BBC3: Bcl-2-binding component 3; GADD45: growth arrest and DNA-damage-inducible 45 alpha; S6K: ribosomal protein S6 kinase; DDIT4: DNA-damage-inducible transcript 4; mTOR: mechanistic target of rapamycin; SOX7: SRY-box 7; CCND1: Cyclin D1