REFERENCES
1. Tasian SK, Loh ML, Hunger SP. Childhood acute lymphoblastic leukemia: integrating genomics into therapy. Cancer 2015;121:3577-90.
2. Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007;446:758-64.
3. Liu Y, Easton J, Shao Y, Maciaszek J, Wang Z, et al. The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia. Nat Genet 2017;49:1211-8.
6. Bhojwani D, Pui CH. Relapsed childhood acute lymphoblastic leukaemia. Lancet Oncol 2013;14:e205-17.
7. Baylin SB, Jones PA. Epigenetic determinants of cancer. Cold Spring Harb Perspect Biol 2016;8:a019505.
8. Luo C, Hajkova P, Ecker JR. Dynamic DNA methylation: In the right place at the right time. Science 2018;361:1336-40.
9. Wong NC, Ashley D, Chatterton Z, Parkinson-Bates M, Ng HK, et al. A distinct DNA methylation signature defines pediatric pre-B cell acute lymphoblastic leukemia. Epigenetics 2012;7:535-41.
10. Davidsson J, Lilljebjörn H, Andersson A, Veerla S, Heldrup J, et al. The DNA methylome of pediatric acute lymphoblastic leukemia. Hum Mol Genet 2009;18:4054-65.
11. Figueroa ME, Chen SC, Andersson AK, Phillips LA, Li Y, et al. Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia. J Clin Invest 2013;123:3099-111.
12. Almamun M, Levinson BT, van Swaay AC, Johnson NT, McKay SD. Integrated methylome and transcriptome analysis reveals novel regulatory elements in pediatric acute lymphoblastic leukemia. Epigenetics 2015;10:882-90.
13. Milani L, Lundmark A, Kiialainen A, Nordlund J, Flaegstad T, et al. DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia. Blood ;115:1214-225.
14. Sandoval J, Heyn H, Méndez-González J, Gomez A, Moran S, et al. Genome-wide DNA methylation profiling predicts relapse in childhood B-cell acute lymphoblastic leukaemia. Br J Haematol 2013;160:406-9.
15. Hogan LE, Meyer JA, Yang J, Wang J, Wong N, et al. Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies. Blood 2011;118:5218-26.
16. Kraszewska MD, Dawidowska M, Larmonie NSD, Kosmalska M, Sędek Ł, et al. DNA methylation pattern is altered in childhood T-cell acute lymphoblastic leukemia patients as compared with normal thymic subsets: insights into CpG island methylator phenotype in T-ALL. Leukemia 2012;26:367-71.
17. Borssén M, Palmqvist L, Karrman K, Abrahamsson J, Behrendtz M, et al. Promoter DNA methylation pattern identifies prognostic subgroups in childhood T-cell acute lymphoblastic leukemia. PLoS One 2013;8:e65373.
18. Teachey DT, Hunger SP. Predicting relapse risk in childhood acute lymphoblastic leukaemia. Br J Haematol 2013;162:606-20.
19. Borssén M, Haider Z, Landfors M, Norén-Nyström U, Schmiegelow K, et al. DNA methylation adds prognostic value to minimal residual disease status in pediatric T-cell acute lymphoblastic leukemia. Pediatr Blood Cancer 2016;63:1185-92.
20. Haider Z, Larsson P, Landfors M, Köhn L, Schmiegelow K, et al. An integrated transcriptome analysis in T-cell acute lymphoblastic leukemia links DNA methylation subgroups to dysregulated TAL1 and ANTP homeobox gene expression. Cancer Med 2019;8:311-24.
21. Audia JE, Campbell RM. Histone Modifications and Cancer. Cold Spring Harb Perspect Biol 2016;8:a019521.
22. Chi P, Allis CD, Wang GG. Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer 2010;10:457-69.
23. Blobel GA. CREB-binding protein and p300: molecular integrators of hematopoietic transcription. Blood 2000;95:745-55.
24. Mullighan CG, Zhang J, Kasper LH, Lerach S, Payne-Turner D, et al. CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature 2011;471:235-9.
25. Gao J, Liu WJ. Prognostic value of the response to prednisone for children with acute lymphoblastic leukemia: a meta-analysis. Eur Rev Med Pharmacol Sci 2018;22:7858-66.
26. Inthal A, Zeitlhofer P, Zeginigg M, Morak M, Grausenburger R, et al. CREBBP HAT domain mutations prevail in relapse cases of high hyperdiploid childhood acute lymphoblastic leukemia. Leukemia 2012;26:1797-803.
27. Gao C, Zhang RD, Liu SG, Zhao XX, Cui L, et al. Low CREBBP expression is associated with adverse long-term outcomes in paediatric acute lymphoblastic leukaemia. Eur J Haematol 2017;99:150-9.
28. Moreno DA, Scrideli CA, Cortez MAA, de Paula Queiroz R, Valera ET, et al. Differential expression of HDAC3, HDAC7 and HDAC9 is associated with prognosis and survival in childhood acute lymphoblastic leukaemia. Br J Haematol 2010;150:665-73.
29. Sonnemann J, Gruhn B, Wittig S, Becker S, Beck JF. Increased activity of histone deacetylases in childhood acute lymphoblastic leukaemia and acute myeloid leukaemia: support for histone deacetylase inhibitors as antileukaemic agents. Br J Haematol 2012;158:664-6.
30. Gruhn B, Naumann T, Gruner D, Walther M, Wittig S, et al. The expression of histone deacetylase 4 is associated with prednisone poor-response in childhood acute lymphoblastic leukemia. Leuk Res 2013;37:1200-7.
31. Bachmann PS, Piazza RG, Janes ME, Wong NC, Davies C, et al. Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition. Blood 2010;116:3013-22.
32. Milne TA, Briggs SD, Brock HW, Martin ME, Gibbs D, et al. MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell 2002;10:1107-17.
33. Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, et al. hDOT1L links histone methylation to leukemogenesis. Cell 2005;121:167-78.
34. Krivtsov AV, Feng Z, Lemieux ME, Faber J, Vempati S, et al. H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell 2008;14:355-68.
35. Benito JM, Godfrey L, Kojima K, Hogdal L, Wunderlich M, et al. MLL-rearranged acute lymphoblastic leukemias activate bcl-2 through h3k79 methylation and are sensitive to the BCL-2-specific antagonist ABT-199. Cell Rep 2015;13:2715-27.
36. Mar BG, Bullinger LB, McLean KM, Grauman PV, Harris MH, et al. Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia. Nat Commun 2014;5:3469.
37. Mar BG, Chu SH, Kahn JD, Krivtsov AV, Koche R, et al. SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia. Blood 2017;130:2631-41.
38. Garcia-Manero G, Kantarjian HM, Sanchez-Gonzalez B, Yang H, Rosner G, et al. Phase 1/2 study of the combination of 5-aza-2’-deoxycytidine with valproic acid in patients with leukemia. Blood 2006;108:3271-9.
39. Schafer E, Irizarry R, Negi S, McIntyre E, Small D, et al. Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting. Blood 2010;115:4798-809.
40. Bernt KM, Zhu N, Sinha AU, Vempati S, Faber J, et al. MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell 2011;20:66-78.
41. Daigle SR, Olhava EJ, Therkelsen CA, Basavapathruni A, Jin L, et al. Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Blood 2013;122:1017-25.
42. Gore SD, Baylin S, Sugar E, Carraway H, Miller CB, et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res 2006;66:6361-9.
43. Bhatla T, Wang J, Morrison DJ, Raetz EA, Burke MJ, et al. Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia. Blood 2012;119:5201-10.
44. Burke MJ, Lamba JK, Pounds S, Cao X, Ghodke-Puranik Y, et al. A therapeutic trial of decitabine and vorinostat in combination with chemotherapy for relapsed/refractory acute lymphoblastic leukemia. Am J Hematol 2014;89:889-95.
45. Vilas-Zornoza A, Agirre X, Abizanda G, Moreno C, Segura V, et al. Preclinical activity of LBH589 alone or in combination with chemotherapy in a xenogeneic mouse model of human acute lymphoblastic leukemia. Leukemia 2012;26:1517-26.
46. Scuto A, Kirschbaum M, Kowolik C, Kretzner L, Juhasz A, et al. The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. Blood 2008;111:5093-100.
47. Annesley CE, Brown P. Novel agents for the treatment of childhood acute leukemia. Ther Adv Hematol 2015;6:61-79.
48. Fouladi M, Park JR, Stewart CF, Gilbertson RJ, Schaiquevich P, et al. Pediatric phase I trial and pharmacokinetic study of vorinostat: a Children’s Oncology Group phase I consortium report. J Clin Oncol 2010;28:3623-9.
49. Xu Y, Vakoc CR. Targeting cancer cells with bet bromodomain inhibitors. Cold Spring Harb Perspect Med 2017;7:a026674.
50. Sahai V, Redig AJ, Collier KA, Eckerdt FD, Munshi HG. Targeting BET bromodomain proteins in solid tumors. Oncotarget 2016;7:53997-4009.
51. Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature 2011;478:524-8.
52. Braun T, Gardin C. Investigational BET bromodomain protein inhibitors in early stage clinical trials for acute myelogenous leukemia (AML). Expert Opin Investig Drugs 2017;26:803-11.
53. Bardini M, Trentin L, Rizzo F, Vieri M, Savino AM, et al. Antileukemic Efficacy of BET Inhibitor in a Preclinical Mouse Model of MLL-AF4+ Infant ALL. Mol Cancer Ther 2018;17:1705-16.
54. Da Costa D, Agathanggelou A, Perry T, Weston V, Petermann E, et al. BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia. Blood Cancer J 2013;3:e126.
55. Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang YL, et al. Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N Engl J Med 2014;371:1005-15.
56. Ott CJ, Kopp N, Bird L, Paranal RM, Qi J, et al. BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia. Blood 2012;120:2843-52.
