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![The epigenome in pediatric acute lymphoblastic leukemia: drug resistance and therapeutic opportunities](https://image.oaes.cc/3d60ffe7-550a-450f-bc5d-6ab326e881d3/3094.fig.1.jpg)
Figure 1. Schematic of Epigenetic Regulation. A: cytosine methylation is mediated by DNA methyltransferases and methyl groups are removed by the activity of demethylase enzymes. Cytosine methylation is generally associated with a closed chromatin state; B: histone acetyltransferases transfer acetyl groups to histones while histone deacetylases remove acetyl groups. Histone acetylation generally promotes an open chromatin state that leads to increased transcriptional accessibility; C: bromodomain-containing proteins function as reader proteins that recognize acetylated histones and promote recruitment of transcriptional co-activators to those sites