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![MEK inhibition activates STAT signaling to increase breast cancer immunogenicity via MHC-I expression](https://image.oaes.cc/110f735f-64b9-49ee-9793-5d4b2035bc3f/3433.fig.1.jpg)
Figure 1. Ras/MAPK activity is inversely related to STAT activation in murine mammary cancer cell lines. A: immunoblot analysis of MMTV-Neu cells treated with or without trametinib (50 nM; MEKi) for 24 or 48 h prior to lysis; B: MMTV-Neu cells stably expressing LacZ or constitutively active MEKDD were treated and analyzed as in A; C: 4T1, EMT6, and E0771 murine mammary cells were treated and analyzed as in A. MAPK: mitogen activated protein kinase; MEKi: MEK inhibition