fig1
![Topoisomerase IB: a relaxing enzyme for stressed DNA](https://image.oaes.cc/47c417d6-e76a-4cba-bef7-4eb2da870194/3309.fig.1.jpg)
Figure 1. Domain representation of hTopIB showing the catalytic pentad. HTopIB comprises an N-terminal domain (1-214; blue), a core domain (215-635; red), a linker domain (636-712; green), and a C-terminal domain (713-765; yellow). The black lines in the core and C-terminal domain highlight the residues that form the catalytic pentad[17]