fig1

Figure 1. Scheme of mechanisms of chemoresistance (MOC): reduction in intracellular concentration of active drugs (MOC-1 and MOC-2), changes in molecular targets (MOC-3), enhanced DNA repair mechanisms (MOC-4), altered balance between survival and apoptosis pathways (MOC-5), tumor microenvironment (MOC-6) and epithelial-mesenchymal transition (MOC-7)