fig2

Figure 2. Putative strategies that may reverse lysosomal drug sequestration. Alkalinizing agents, nanotechnology, Dp44mT, photodestruction, lysosomotropic agents, and acid-labile conjugates may be employed to bypass lysosomal-mediated drug resistance. The purple medicine bottles represent chemotherapeutic drugs that are trapped in the lysosomal lumen and the black medicine bottle represents drugs that presumably will be sent back into the cytosol. Dp44mT: di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone