fig1
![Overcome cancer drug resistance by targeting epigenetic modifications of centrosome](https://image.oaes.cc/574831fa-1b79-447e-abb5-aac0d3202a17/3079.fig.1.jpg)
Figure 1. Centrosome structure. A: the centrosome consists a pair of orthogonal centrioles, surrounded by mass proteins, referred to as the pericentriolar material (PCM). PCM proteins subdivide the PCM to three layers depending on diameter of the ring-like structures. Mother centrioles possess subdistal appendages and distal appendages; B: each centriole is a cylindrical structure with nine-fold microtubule organized like a central cartwheel. The triplet microtubules are composed of internal A, middle B, and external C microtubules. The figure is adapted and modified[9]