fig2

Figure 2. Incidence of CD22ΔE12 in BCR-ABL⁺/Ph⁺ and Ph-like ALL Patients. (A) The expression values for each of the 110 probesets were averaged across 123 BCR-ABL⁺ ("Ph⁺") cases from the normalized database of 1416 patients to provide an expression template for subsequent correlation analysis; (B) BLAT analysis on CD22 probe sequences for probeset 217422_s_at (covering exons10-14) deposited in the Affymetrix NetAffx™ Analysis Center were mapped onto specific CD22 exons and visualized using the UCSC genome browser (http://genome.ucsc.edu/cgibin/hgBlat?command=start). A CD22ΔE12 Index was calculated by subtracting the median centered expression values of the 7 probes for CD22 Exons 10-11 and CD22 Exons 13-14 in the 217422_s_at probeset from the median centered expression values of the 3 CD22 Exon 12 probes. Depicted is the Quantile dot plot (Box represents 25th, median and 75th percentiles, and the whiskers represent the minimum, 10th, 90th and maximum values) of the sample level CD22ΔE12-index values in primary leukemic samples from 123 Ph⁺ and 370 Ph-like ALL patients