fig1

Figure 1. Neural circuit basis of cognitive pain modulation. (A) Recent research published in Nature by Chen et al. identified the cortico-ponto-cerebellar pathway in the regulation of cognitive aspects of pain^[1]; (B) A placebo analgesia conditioning assay designed for rodents to generate placebo-like anticipatory pain relief, allowing for the evaluation of the resulting analgesic effect. Ctrl, the control group; Cond, placebo analgesia condition group; (C) Schematic of the recording configuration for rACC → PN → Purkinje circuitry. rACC: Rostral anterior cingulate cortex; PN: pontine nucleus; IN: local interneurons.