fig2

Figure 2. Schematic diagram showing the impacts of Aβ deposition in the brain and peripheral organs. In the central nervous system, abnormal deposition of Aβ in the brain leads to mitochondria dysfunction, which then further causes synaptic degeneration to induce changes in the auditory pathway. Aβ could also exert influences on peripheral organs either directly or indirectly through lymphatic fluid with inflammatory factors, such as IL-1β and TNF-α released by activated microglia cells. Aβ: Beta-amyloid.