fig4

Figure 4. Therapeutic options to mediate intracellular uptake and extracellular release. (1) Competitive binding agents inhibit intracellular uptake via LAG3 and HSPGs^{[41,45,98-100]}. Lysine modification on LRP1 inhibits LRP1-driven intracellular uptake^[43]; (2) Tetrodotoxin and Tetanus toxin impair the extracellular release of pathologic tau from axon terminals by blocking the Na⁺/K⁺ ATPase and AMPAR pathways, respectively^[46,47]. Created with BioRender.com. AMPAR: AMPA receptors; HSPG: heparan sulfate proteoglycan; LAG3: lymphocyte-activation gene 3; LRP1: lipoprotein receptor-related protein 1; TTX: tetrodotoxin.