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![Unraveling the tau puzzle: a review of mechanistic targets and therapeutic interventions to prevent tau pathology in Alzheimer's disease](https://image.oaes.cc/48be6d03-d7e6-492c-8b63-9c49991c8e0a/and3020.fig.2.jpg)
Figure 2. Schematic of ASO-mediated degradation of MAPT mRNA in the nucleus. ASO sequences bind to specific sequences along MAPT mRNA in the nucleus to facilitate the degradation of this mRNA and reduce the production of tau[8,31-34]. Created with BioRender.com. ASO: Antisense oligonucleotide; MAPT: microtubule-associated protein tau.