fig10
Figure 10. Sequence-dependent abnormal aggregation of human ataxin-3(45Q) takes place in SH-SY5Y cells. (A) Wild-type ataxin-3(45Q), (B) ataxin-3(45Q)-F74P mutant, (C) and ataxin-3(45Q)-I92P mutant overexpressed in SH-SY5Y cells formed aggregates in the cells; In contrast, no aggregates were observed in (D) ataxin-3(45Q)-I80P. The experimental conditions are the same as those in Figure 9.
