fig5

Figure 5. (A and B) Treg infusions suppressed serum 4-HNE levels, but they then rose during the “washout” period when not on Treg therapy in two of the three phase I subjects;. (C) Subject three did not have elevated 4-HNE levels throughout the study. MDA was longitudinally elevated in the sera of all three subjects throughout the study and the levels were not altered by Treg therapy. Arrows indicate Treg infusion dates. The red dotted lines demarcate Treg + IL-2 therapy or IL-2 only intervals. Red line = mean value of each analyte in HC. Black lines ± one standard deviation of each analyte level in HC. The means and standard deviations vary due to the differences in ELISA plates used. AALS: Appel ALS clinical scoring system.