fig2

Figure 2. Oxidative stress analytes. (A) 4-HNE was elevated in patients compared with HC; (B) 4-HNE was elevated in rapidly progressing patients compared with slowly progressing patients; 4-HNE was not elevated in slowly progressing patients compared with HC; (C) MDA was elevated in patients compared with HC; (D) MDA levels were elevated and comparable in both rapidly and slowly progressing patients; levels in both were elevated compared with HC; (E - G) 4-HNE positively correlated with disease progression, but MDA levels did not correlate with progression. 4-HNE and MDA did not correlate with each other. ** P < 0.01, *** P < 0.001, and n.s.: not significant.