fig1
Figure 1. The role of PGC1α in the mitochondria of AD neurons, including effects on mitochondrial energy metabolism, biogenesis and ion homeostasis. mt: Mitochondrial; mtSSB: mitochondrial ssDNA-binding protein; NRF: nuclear respiratory factor; PGC1α: peroxisome proliferator-activated receptor gamma coactivator 1-alpha; POLG: mitochondrial polymerase, polymerase-γ; PPARγ: the nuclear receptor peroxisome proliferator-activated receptor-γ; ROS: reactive oxygen species; TFAM: mitochondrial transcription factor A; Twinkle: twinkle helicase; ΔΨm: mitochondrial membrane potential.
